Heterocyclic Compounds

The Basicity of Pyridine

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Welcome, students! Today we are diving into one of the most important heterocyclic compounds in pharmacy: Pyridine. If you’ve ever wondered why certain drugs work the way they do, or why some molecules react while others stay quiet, understanding the “personality” of Pyridine is your first step. To understand its basicity, we must look at … Read more

Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene

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The relative aromaticity and reactivity of the five-membered heterocyclic compounds—Pyrrole, Furan, and Thiophene—are governed by the electronegativity of the heteroatom and the effectiveness of the p-orbital overlap with the carbon atoms. Relative Aromaticity Aromaticity depends on how much a molecule “prefers” to keep its lone pair of the π -electrons delocalized into the ring to … Read more